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PSEC13

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Model organisms1

Outcomes

2

Heat shock response and chaperones

upin worms1

1 study

  1. PSEC13 activates heat shock response and chaperones in worms.

    “Moreover, PSEC13 activated the HSF-1/DAF-16 axis, upregulating heat shock proteins (HSPs).”

    Model organisms

    Undescribed Phenylpropanoid-Substituted Ester-Type Catechins from Green Tea Exert Antiaging Effects in Caenorhabditis elegans via Activating DAF-16, HSF-1, and Heat Shock Proteins

    Journal of agricultural and food chemistry11 Jun 2025

More on Heat shock response and chaperones

Lifespan

upin worms1+57% longest lifespan

1 study

  1. PSEC13 extends lifespan in worms (+57% longest lifespan).

    “among which PSEC13 extended the longest lifespan by 57%”

    Model organismsS configuration

    Undescribed Phenylpropanoid-Substituted Ester-Type Catechins from Green Tea Exert Antiaging Effects in Caenorhabditis elegans via Activating DAF-16, HSF-1, and Heat Shock Proteins

    Journal of agricultural and food chemistry11 Jun 2025

Associations

1

hsp-16.2

upin silico1

1 study

  1. PSEC13 is associated with hsp-16.2 in silico.

    “Molecular dynamics simulations revealed that PSEC13 forms stable hydrogen bonds with key residues (GLU39, SER41, ASN55) in the HSP-16.2 active site.”

    In silicoMolecular dynamics simulations; hydrogen bonds at GLU39, SER41 and ASN55

    Undescribed Phenylpropanoid-Substituted Ester-Type Catechins from Green Tea Exert Antiaging Effects in Caenorhabditis elegans via Activating DAF-16, HSF-1, and Heat Shock Proteins

    Journal of agricultural and food chemistry11 Jun 2025

More on hsp-16.2

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