LRRK2
Gene2 papers3 findingsHGNC 18618NCBI Gene 120892Taxon 9606
- Humans1
- Animals1
Effects
3Mortality
downin humans1HR 0.76
1 study
Mortality
downin humans1HR 0.76
LRRK2 decreases mortality in humans (HR 0.76, 95% CI 0.59-0.96).
Humansin Parkinson's disease compared to idiopathic PD
The Effect of LRRK2 and GBA1 Mutations on Survival in Early- and Late-Onset Parkinson's Disease · Movement disorders : official journal of the Movement Disorder Society · 1 Sep 2026
Purine metabolism
downin mice1
1 study
Purine metabolism
downin mice1
LRRK2 decreases purine metabolism in mice.
AnimalsLRRK2 G2019S knock-inoptic nervemales
Sex- and age-dependent energetic dysfunction in LRRK2 G2019S Parkinson’s model revealed by structural analysis of RGC dendritic architecture and metabolic profiling of optic nerve · Research Square · 25 Aug 2026 · Preprint
RGC structural abnormalities
upin mice1
1 study
RGC structural abnormalities
upin mice1
LRRK2 increases RGC structural abnormalities in mice.
AnimalsLRRK2 G2019S knock-inretinamales
Sex- and age-dependent energetic dysfunction in LRRK2 G2019S Parkinson’s model revealed by structural analysis of RGC dendritic architecture and metabolic profiling of optic nerve · Research Square · 25 Aug 2026 · Preprint
Funding
National Institute of Neurological Disorders and StrokeUS$901.7k2 grants since 2022