Hydroxyproline
Biomarker1 paper1 finding
- Model organisms1
Interventions
1Pimozide
upin worms1
1 study
Pimozide
upin worms1
Pimozide increases hydroxyproline in worms.
“Transcriptomic profiling and biochemical validation reveal that pimozide markedly upregulates collagen gene expression and increases hydroxyproline content, indicating enhanced collagen synthesis.”
Model organisms
Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes · Antioxidants (Basel, Switzerland) · 21 Sep 2026
Latest
1Model organisms
Antipsychotic drug pimozide extends lifespan and boosts stress resistance in nematodes
The treatment relies on SKN-1 activation to increase collagen synthesis and enhance healthspan markers in Caenorhabditis elegans.