Huntington's disease

Disease3 papers

Animals1

Latest

A New Soaking Protocol to Live Stain C. elegans with Proteostat Dye Reveals Global Patterns of Stress-Induced Protein Aggregation

Model organismsPreprintbioRxiv5 h

Neuroinflammation and Autophagy in Neurodegeneration: Cellular Mechanisms and Therapeutic Strategies

ReviewCNS & neurological disorders drug targets1 Oct

Ubiquitin-Dependent Protein Quality Control in Polyglutamine Diseases

ReviewAging and disease30 Sep

AnimalsPeer-reviewed28 Sep

Synthetic gene circuit clears protein aggregates and extends lifespan in Huntington disease mice

The sensor-driven system selectively triggers autophagy regulator TFEB upon detecting toxic huntingtin conformers, lowering brain inflammation and rescuing synaptic deficits.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) · Zhu J et al.

Paper

Withania somnifera (Ashwagandha) Improves Fitness in Aged Drosophila by Reducing AKT Phosphorylation

Model organismsInternational journal of molecular sciences28 Sep