Ultrafine particles
Intervention1 paper4 findings
A human study links ultrafine particles to increased risks of dementia and vascular dementia, but reports no effect on amyotrophic lateral sclerosis or Parkinson’s disease.
- Humans1
Outcomes
2Amyotrophic lateral sclerosis
no changein humans1Low certainty
1 study
Amyotrophic lateral sclerosis
no changein humans1Low certainty
Ultrafine particles have no effect on amyotrophic lateral sclerosis in humans.
Humans2001-2019
Ultrafine particle exposure linked to dementia mortality · Epidemiology (Cambridge, Mass.) · 5 Oct 2026
Parkinson's disease
no changein humans1Low certainty
1 study
Parkinson's disease
no changein humans1Low certainty
Ultrafine particles have no effect on Parkinson's disease in humans.
Humans2001-2019
Ultrafine particle exposure linked to dementia mortality · Epidemiology (Cambridge, Mass.) · 5 Oct 2026
Associations
2Vascular dementia
upin humans1HR 1.49Low certainty
1 study
Vascular dementia
upin humans1HR 1.49Low certainty
Ultrafine particles are associated with vascular dementia in humans (HR = 1.49, 95% CI: 1.27-1.76).
Humansper 10,000 particle/cm 3 increase2001-2019
Ultrafine particle exposure linked to dementia mortality · Epidemiology (Cambridge, Mass.) · 5 Oct 2026
Dementia
upin humans1HR 1.22Low certainty
1 study
Dementia
upin humans1HR 1.22Low certainty
Ultrafine particles are associated with dementia in humans (HR = 1.22, 95% CI: 1.17-1.27).
Humansper 10,000 particle/cm 3 increase2001-2019
Ultrafine particle exposure linked to dementia mortality · Epidemiology (Cambridge, Mass.) · 5 Oct 2026
Latest
1Ultrafine particle exposure linked to dementia mortality
Each 10,000 particles/cm³ increase in outdoor ultrafine particle concentrations was associated with higher dementia mortality (hazard ratio 1.22, 95%…Each 10,000 particles/cm³ increase in outdoor ultrafine particle concentrations was associated with higher dementia mortality (hazard ratio 1.22, 95% CI 1.17–1.27).