Muscular atrophy

Disease2 papers1 findingMeSH D009133

Animals1
In silico1

Interventions

Inotodiol

downin mice1

1 study

Inotodiol protects against muscular atrophy in mice.
Animalsdexamethasone-inducedskeletal muscle
Inotodiol preserves muscle mass and function in aged mice · Signal transduction and targeted therapy · 25 Sep 2026

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Latest

Transcription factor activity divergence across muscle atrophy conditions: A comparative analysis of spaceflight, aging, and disuse using decoupleR

In silicoPloS oneYesterday

CellsPreprint1 Oct

Androgen receptor polyglutamine tract controls muscle growth and atrophy pathways

Researchers found that expanding polyglutamine tracts in the androgen receptor shift binding toward senescence-linked enhancers, driving muscle atrophy in cells and mice.

bioRxiv · Grafton F et al.

Paper

Ubiquitin-Dependent Protein Quality Control in Polyglutamine Diseases

ReviewAging and disease30 Sep

AnimalsPeer-reviewedMitochondria26 Sep

Inotodiol preserves muscle mass and function in aged mice

The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.

Signal transduction and targeted therapy · You CL et al.

Paper