Blood flow restriction training

Intervention4 papers10 findings

A human trial in hospitalised older adults with sarcopenia shows blood flow restriction training improves Modified Barthel Index, physical performance, grip strength, gait speed and Timed Up-and-Go versus resistance training. A separate human trial reports increased lactate in men after 12 weeks.

  • Human trial4

Outcomes

10

Lactate

upin humans1Low certainty

1 study
  1. Blood flow restriction training increases lactate in humans.

    Human trial12 weeksmales

    Comparing high-intensity resistance training incorporating periodic eccentric-only exercise with blood flow restriction training in older men: physiological responses and exercise feasibility · European journal of applied physiology · 24 Sep 2026

Lactate →

Health-related quality of life

upin humans1Low certainty

1 study
  1. Blood flow restriction training improves health-related quality of life in humans (p-value <0.001).

    Human trialend-stage chronic kidney disease on hemodialysis8 weeksn = 36

    Effect of Intradialytic Blood Flow Restriction Training on Functional Capacity, Estimated Glomerular Filtration Rate and Health-Related Quality of Life in Patients on Hemodialysis: A Randomized Controlled Trial · Research Square · 28 Aug 2026 · Preprint

Physical function

upin humans1Low certainty

1 study
  1. Blood flow restriction training improves physical function in humans (p-value <0.05).

    Human trialend-stage chronic kidney disease on hemodialysis8 weeksn = 36

    Effect of Intradialytic Blood Flow Restriction Training on Functional Capacity, Estimated Glomerular Filtration Rate and Health-Related Quality of Life in Patients on Hemodialysis: A Randomized Controlled Trial · Research Square · 28 Aug 2026 · Preprint

Estimated glomerular filtration rate

upin humans1Low certainty

1 study
  1. Blood flow restriction training improves estimated glomerular filtration rate in humans (p-value <0.05).

    Human trialend-stage chronic kidney disease on hemodialysis8 weeksn = 36

    Effect of Intradialytic Blood Flow Restriction Training on Functional Capacity, Estimated Glomerular Filtration Rate and Health-Related Quality of Life in Patients on Hemodialysis: A Randomized Controlled Trial · Research Square · 28 Aug 2026 · Preprint

Estimated glomerular filtration rate →

Fractional anisotropy

upin humans1Low certainty

1 study
  1. Blood flow restriction training increases fractional anisotropy in humans.

    Human trialthree-group trialparietal region12 weeksmalesn = 48

    Differential Effects of Blood-Flow Restriction and High-Intensity Resistance Training on Cortical Thickness and White Matter Integrity in Older Men: A Three-Group Randomized Controlled Trial · Brain sciences · 28 Jul 2026

Fractional anisotropy →

Modified Barthel Index

upin humans1Low certainty

1 study
  1. Blood flow restriction training improves Modified Barthel Index in humans.

    Human trialhospitalized older adults with sarcopenia, compared with resistance training3 times per week12 weeksn = 40

    [Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function in Older Adults With Sarcopenia] · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 20 Jul 2026

Modified Barthel Index →

Timed Up-and-Go

upin humans1Low certainty

1 study
  1. Blood flow restriction training improves Timed Up-and-Go in humans.

    Human trialhospitalized older adults with sarcopenia, compared with resistance training3 times per week12 weeksn = 40

    [Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function in Older Adults With Sarcopenia] · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 20 Jul 2026

Timed Up-and-Go →

Gait speed

upin humans1Low certainty

1 study
  1. Blood flow restriction training improves gait speed in humans.

    Human trialhospitalized older adults with sarcopenia, compared with resistance training3 times per week12 weeksn = 40

    [Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function in Older Adults With Sarcopenia] · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 20 Jul 2026

Gait speed →

Short Physical Performance Battery

upin humans1Low certainty

1 study
  1. Blood flow restriction training improves Short Physical Performance Battery in humans.

    Human trialhospitalized older adults with sarcopenia, compared with resistance training3 times per week12 weeksn = 40

    [Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function in Older Adults With Sarcopenia] · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 20 Jul 2026

Short Physical Performance Battery →

Grip strength

upin humans1Low certainty

1 study
  1. Blood flow restriction training improves grip strength in humans ([25.25 ± 5.34] kg vs. [21.66 ± 5.19] kg).

    Human trialhospitalized older adults with sarcopenia, compared with resistance training3 times per week12 weeksn = 40

    [Effects of Blood Flow Restriction Training on Muscle Strength and Physical Function in Older Adults With Sarcopenia] · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 20 Jul 2026

Grip strength →

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