C-conect

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Human trial2

Outcomes

Depressive symptoms

downin humans2−62% participants reported reduced depressive symptoms

2 studies

C-conect decreases depressive symptoms in humans (62% of participants reported reduced depressive symptoms).
“After the intervention, 62% of participants reported reduced depressive symptoms.”
Human trialsix weeks75% femalesn = 8
Online Conversations for Cognitive Health: A Culturally Adapted Intervention for Older Chinese Immigrants
GSA 2025 abstract31 Dec 2025
C-conect decreases depressive symptoms in humans (62%).
“Lower post‐intervention depressive symptoms were reported in 62% of the sample.”
Human trial6 weeks75% femalesn = 8
Feasibility and Acceptability of an Online Conversation Intervention to Promote Social Connectedness and Prevent Cognitive Decline among Older Chinese Immigrants
AAIC 2025 abstract25 Dec 2025