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Brain aging

Papers on brain aging

3,753 papers126 new in 30 days

Wednesday, November 4

Molecular & Cellular Proteomics

Protein changes during mouse brain aging vary by region

Mapping 11 brain regions across five time points revealed changes to Tau’s molecular tags that might impair its breakdown in the hippocampus.Mapping 11 brain regions across five time points revealed changes to Tau’s molecular tags that might impair its breakdown in the hippocampus.

Figure from Molecular & Cellular Proteomics
Mouse studyAI & data
Paper
Biological Psychiatry

Depression linked to larger brain age gaps, more so with age

An age-adjusted measure of brain aging was 2.0 years higher in 645 medication-free people with depression than in 645 matched healthy controls.An age-adjusted measure of brain aging was 2.0 years higher in 645 medication-free people with depression than in 645 matched healthy controls.

Figure from Biological Psychiatry
Cross-sectional · 645 peopleMajor depressive disorder
Paper

Tuesday, November 3

bioRxiv

Brain glucose signals were less complex in older adults

An observational study of 84 adults linked more complex glucose signals to greater variation in brain network coordination; cognitive associations largely reflected age…An observational study of 84 adults linked more complex glucose signals to greater variation in brain network coordination; cognitive associations largely reflected age differences.

A brain cross-section has thicker folds with varied glucose clusters on one side and thinner folds with sparse, regular clusters on the other.
Preprint: cross-sectional · 84 peopleBiomarkers
Paper
bioRxiv

Brain scan charts map white matter spots across adult life

An observational analysis of 42,469 brain lesion maps from 12 adult cohorts produced reference charts comparing the amount and location of white matter changes.An observational analysis of 42,469 brain lesion maps from 12 adult cohorts produced reference charts comparing the amount and location of white matter changes.

A brain cross-section with dense white matter spots sits beside two smaller sections showing sparse spots and a more widely scattered pattern.
Preprint: cross-sectional study of 42,469 peopleAI & data
Paper
NPJ Aging

Faster brain aging linked to death and disease across the body

An observational analysis of brain scans from over 60,000 UK Biobank participants linked accelerated brain aging to death and diseases affecting multiple organ systems.An observational analysis of brain scans from over 60,000 UK Biobank participants linked accelerated brain aging to death and diseases affecting multiple organ systems.

Figure from NPJ Aging
Cohort studyBiomarkers
Paper
Journal of Alzheimer's Disease

White matter injury linked to older-appearing brains

Among 601 people, each unit increase in white matter injury on a logarithmic scale was linked to a 6.95-year larger brain-age gap.Among 601 people, each unit increase in white matter injury on a logarithmic scale was linked to a 6.95-year larger brain-age gap.

Figure from Journal of Alzheimer's Disease
Cross-sectional · 601 peopleBiomarkers
Paper
Research Square

Inhibiting brain neurons restored immune cell production in aged mice

In experiments in aged mice, inhibiting specific brain neurons or deleting a gene involved in inflammatory signaling improved the response to a flu vaccine.In experiments in aged mice, inhibiting specific brain neurons or deleting a gene involved in inflammatory signaling improved the response to a flu vaccine.

Bone marrow with sparse versus abundant immune cells sits beneath mice and branching neurons, with inflammation clustered above the sparse region.
Preprint: mouse studyBlood and immune system
Paper
Aging Cell

A protein helped limit aging-related changes in stem cells

Experiments in stem cells found that increasing a protein preserved the structure of their DNA-containing nuclei and counteracted senescence, a state in which cells stop…Experiments in stem cells found that increasing a protein preserved the structure of their DNA-containing nuclei and counteracted senescence, a state in which cells stop dividing.

TOP2A expression is decreased in senescent human MSCs.
Experiments in cellsMechanisms
Paper

Monday, November 2

Aging Cell

Aging shifts the brain’s natural glow toward red in mice

Experiments in 3- and 21-month-old female mice found larger clumps of fluorescent material in brain immune cells and age-related changes in emitted light.Experiments in 3- and 21-month-old female mice found larger clumps of fluorescent material in brain immune cells and age-related changes in emitted light.

Ageing leads to a reduction in the number of new hippocampal neurons and to changes in hippocampal gene expression in otherwise healthy mice.
Mouse studyBiomarkers
Paper

Sunday, November 1

Journal of Hazardous Materials

Chemical exposure induced an aging state in animal nerve cells

Deleting a gene reduced this response in animal experiments examining how an emerging environmental chemical affected nerve cells.Deleting a gene reduced this response in animal experiments examining how an emerging environmental chemical affected nerve cells.

Figure from Journal of Hazardous Materials
Animal studyMechanisms
Paper

Saturday, October 31

Friday, October 30

Thursday, October 29

Biology

Brain age profiles capture disease-linked patterns in people

Adding imaging profiles improved scores for distinguishing disease groups by 0.018–0.060 compared with a baseline using age, brain age deviation, sex and imaging center.Adding imaging profiles improved scores for distinguishing disease groups by 0.018–0.060 compared with a baseline using age, brain age deviation, sex and imaging center.

Figure from Biology
Cohort · 37,894 peopleBiomarkers
Paper
Aging Cell

Increasing a brain protein delayed signs of aging in mice

Removing the protein from brain support cells accelerated aging-related changes and impaired nervous system function in mouse experiments.Removing the protein from brain support cells accelerated aging-related changes and impaired nervous system function in mouse experiments.

Figure from Aging Cell
Mouse studyMechanisms
Paper
Neuroinformatics

Brain scan model estimates aging across brain regions

Trained on scans from 14,423 adults with normal cognition, the model performed better than an existing method in repeat-scan testing.Trained on scans from 14,423 adults with normal cognition, the model performed better than an existing method in repeat-scan testing.

Figure from Neuroinformatics
Computational studyBiomarkers
Paper

Wednesday, October 28