In lab experiments, reducing alpha-synuclein, a protein, made layers of human brain blood-vessel cells leakier; suppressing an enzyme returned leakage to normal.In lab experiments, reducing alpha-synuclein, a protein, made layers of human brain blood-vessel cells leakier; suppressing an enzyme returned leakage to normal.
In CamCAN, adding brain-shape measures cut average age-prediction errors from 6.04 to 4.71 years compared with an anatomy-based model.In CamCAN, adding brain-shape measures cut average age-prediction errors from 6.04 to 4.71 years compared with an anatomy-based model.
Across 12 cohorts, type 2 diabetes was linked to a brain age gap 1.73 years higher than in people without diabetes.Across 12 cohorts, type 2 diabetes was linked to a brain age gap 1.73 years higher than in people without diabetes.
The spread of age-linked effects at the same RNA joining sites was 2.0–2.8 times as wide in brain as in body tissues from the same donors.The spread of age-linked effects at the same RNA joining sites was 2.0–2.8 times as wide in brain as in body tissues from the same donors.
Brain scans linked dopamine production capacity and Alzheimer’s-related protein buildup to distinct patterns of network organization in young and cognitively unimpaired…Brain scans linked dopamine production capacity and Alzheimer’s-related protein buildup to distinct patterns of network organization in young and cognitively unimpaired older adults.
Across 77 human cases, the average share of cells with deposits was near zero until age 40 and exceeded 50% after age 70.Across 77 human cases, the average share of cells with deposits was near zero until age 40 and exceeded 50% after age 70.
An analysis of 24 rhesus macaques identified 594 age-associated changes in levels of RNA versions, some shared between sexes and others sex-specific.An analysis of 24 rhesus macaques identified 594 age-associated changes in levels of RNA versions, some shared between sexes and others sex-specific.
Experiments in genetically modified mice linked brain aging to greater activity of an inflammation-regulating pathway and reduced activity of another.Experiments in genetically modified mice linked brain aging to greater activity of an inflammation-regulating pathway and reduced activity of another.
An observational analysis of 86 hippocampus samples spanning about 3–35 years linked older age to greater variation in chemical marks on DNA.An observational analysis of 86 hippocampus samples spanning about 3–35 years linked older age to greater variation in chemical marks on DNA.
In two groups of 818 and 497 adults without cognitive impairment, Alzheimer’s-like brain activity patterns were associated with faster cognitive decline.In two groups of 818 and 497 adults without cognitive impairment, Alzheimer’s-like brain activity patterns were associated with faster cognitive decline.
Who was studied818 cognitively unimpaired adults, against SA-like cognitively unimpaired adults
What changedThinking skills declined faster in cognitively unimpaired adults with Alzheimer-like brain patterns than in those with SuperAger-like patterns
The catchUnmodeled vascular disease could contribute to both brain patterns and cognitive decline
An observational analysis of brain tissue from 29 neurologically healthy donors linked age-related changes in non-neuronal cells to molecular patterns associated with…An observational analysis of brain tissue from 29 neurologically healthy donors linked age-related changes in non-neuronal cells to molecular patterns associated with Alzheimer’s disease.
Who was studied29 neurologically healthy human brain donors
What changedAge-gained brain-cell marks overlapped Alzheimer’s-associated regions at 250 sites, versus fewer than 15 overlaps on average with random fragments
The catchChromatin-mark measurements lacked matched input controls to distinguish signal from background
An observational study of 46 healthy adults aged 20–77 linked older age to less restricted water movement and larger microscopic structural scales.An observational study of 46 healthy adults aged 20–77 linked older age to less restricted water movement and larger microscopic structural scales.
Compared with controls, mouse models of Alzheimer’s disease, diabetes-related brain impairment and brain aging had less of a protein that helps organize nerve-cell…Compared with controls, mouse models of Alzheimer’s disease, diabetes-related brain impairment and brain aging had less of a protein that helps organize nerve-cell connections.
