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6-shogaol

Intervention

1 paper5 findings

PubChem 5281794ChEBI 10138

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Henan Provincial Science and Technology Research Project and 1 more
  • Animals1

Outcomes

5

Butyrate-producing microbiota

upin mice1

1 study

  1. 6-shogaol increases butyrate-producing microbiota in mice.

    “16 s rRNA sequencing analysis revealed relative abundance of butyrate-producing microbiota (i.e., Muribaculaceae, Lachnospiraceae_NK4A136_group, Clostridium_sensu_stricto_1, Lachnospiraceae and Dubosiella) were significantly up-regulated”

    Animalsoral gavage10, 20 mg/kg.bw.2 months

    6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier

    Phytomedicine : international journal of phytotherapy and phytopharmacology8 Oct 2025

Short-chain fatty acid metabolism

upin mice1

1 study

  1. 6-shogaol activates short-chain fatty acid metabolism in mice.

    “Untargeted and SCFAs-targeted metabolomics showed that butanoate metabolism was significantly upregulated by 6-shogaol.”

    Animalsoral gavage10, 20 mg/kg.bw.2 months

    6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier

    Phytomedicine : international journal of phytotherapy and phytopharmacology8 Oct 2025

More on Short-chain fatty acid metabolism

Intestinal barrier integrity

upin mice1

1 study

  1. 6-shogaol improves intestinal barrier integrity in mice.

    “The observed metabolic regulatory effect of 6-shogaol was concomitant with augmentation of the intestinal barrier, as evidenced by the gut homeostasis, barrier integrity and up-regulated tight junction proteins.”

    Animalsoral gavageintestine10, 20 mg/kg.bw.2 months

    6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier

    Phytomedicine : international journal of phytotherapy and phytopharmacology8 Oct 2025

Hippocampal tissue damage

downin mice1

1 study

  1. 6-shogaol protects against hippocampal tissue damage in mice.

    “6-shogaol maintained the neurotransmitter homeostasis and protected hippocampus tissue.”

    Animalsoral gavagehippocampus10, 20 mg/kg.bw.2 months

    6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier

    Phytomedicine : international journal of phytotherapy and phytopharmacology8 Oct 2025

Cognitive function

upin mice1

1 study

  1. 6-shogaol improves cognitive function in mice.

    “Declines of cognitive and memory capacities were significantly relieved by intervention of 6-shogaol in a dose-dependent manner during the natural aging process.”

    Animalsoral gavage10, 20 mg/kg.bw.2 months

    6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier

    Phytomedicine : international journal of phytotherapy and phytopharmacology8 Oct 2025

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