Papers on brain aging

3,754 papers124 new in 30 days

Wednesday, October 28

VirologyOct 28

Neurotropic herpesviruses as accelerators of brain aging: The role of latency and reactivation in neurodegeneration

ReviewMechanisms

Paper

Tuesday, October 27

IEEE Journal of Biomedical and Health InformaticsOct 27

Model estimates brain age from overnight brain-wave recordings

The model’s predictions differed from actual ages by 5.89 years on average, and by 5.41 years in an independent validation group.The model’s predictions differed from actual ages by 5.89 years on average, and by 5.41 years in an independent validation group.

A brain seen from above with electrode discs and a dark branching detail sits beside a smaller gray brain and clusters of upright, faceless people.

Computational studyBiomarkers

Paper

bioRxivOct 27

Cerebello-basal ganglia networks and behavior across adulthood and aging

Patterns of functional connectivity (FC) between ROIs associated with cognitive behavior and networks.

Preprint: cross-sectional study of 138 peopleMechanisms

Paper

BiomoleculesOct 27

Effects of Fixed-Speed Treadmill Exercise on Oxidative Stress and Sirtuin Biomarkers in Young and D-Galactose-Treated Rats: A Biochemical Study with Exploratory Hippocampal Observations

Graph of mean values for MDA and PGC-1α.

Experiments in 64 ratsTreadmill exercise

Paper

International Journal of Neural SystemsOct 27

Mapping Lifespan Functional Connectivity with Vision Transformer and Attention-Guided Trajectory Analysis

Computational studyBiomarkers

Paper

Brain SciencesOct 27

Brain Aging and Cellular Senescence Trigger Neuroimmunological Dysregulation and Neurodegeneration

ReviewCellular senescence

Paper

Neurobiology of AgingOct 27

Resting EEG as a condition-dependent ageing phenotype

Cohort study in peopleBiomarkers

Paper

arXivOct 27

Interpretable Brain Age Prediction Using White Matter Fiber Orientation Distributions with Rotation-Equivariant Deep Learning

Preprint: study of 692 peopleBiomarkers

Paper

Brain InformaticsOct 27

STABLE-BAG: a stability-aware framework for SHAP-based brain age gap decomposition

Computational studyAI & data

Paper

Monday, October 26

bioRxivOct 26

Functional and Structural Brain Age Gaps as Complementary Predictive Markers for Cognitive Performance

Relation of cognitive profiles to regional structural and functional brain phenotypes.

Preprint: cross-sectional study of 901 peopleBiomarkers

Paper

Cerebral CortexOct 26

Thickness of the brain’s outer layer is linked to cognitive aging

An observational analysis of adult cohorts linked thickness more strongly than surface area to changes in thinking abilities over time.An observational analysis of adult cohorts linked thickness more strongly than surface area to changes in thinking abilities over time.

Directed acyclic graph illustrating a structural equation model (SEM) testing dissociable pathways from age and polygenic score (PGS) to g via thickness and area.

Cohort studyMechanisms

Paper

Communications BiologyOct 26

Myelin cells rank among the most conserved in primates and mice

An observational comparison of about one million gene-activity profiles found stronger conservation in precursor cells than in mature cells.An observational comparison of about one million gene-activity profiles found stronger conservation in precursor cells than in mature cells.

Cross-sectional studyMechanisms

Paper

ESC Congress 2026 AbstractOct 26

Older-than-expected heart age linked to dementia risk

Dementia hazard ratios—a measure of relative risk—were 2.56 in UK Biobank and 1.19 in Severance versus participants without accelerated heart aging.Dementia hazard ratios—a measure of relative risk—were 2.56 in UK Biobank and 1.19 in Severance versus participants without accelerated heart aging.

A large dark blue-green heart sits below a gray brain with wide gaps between folds, beside a smaller heart and a brain with denser folds.

Cohort studyDementia

Paper

ESC Congress 2026 AbstractOct 26

Adipose tissue distribution, cognitive decline and structural brain changes in individuals with cardiovascular disease: the SMART-MR study

Cohort study of 1,307 peopleCardiovascular disease

Paper

Molecular PsychiatryOct 26

Severe mental disorders share genetic links to cellular aging

A genome-wide analysis linked bipolar disorder, depression and schizophrenia to cellular aging markers, identifying nine genes shared across all three conditions.A genome-wide analysis linked bipolar disorder, depression and schizophrenia to cellular aging markers, identifying nine genes shared across all three conditions.

Genetic association studyMechanisms

Paper

Redox BiologyOct 26

Glial lipid reprogramming in brain aging: Lipid identity, organelle stress, and redox vulnerability

ReviewMechanisms

Paper

Sunday, October 25

Journal of Cellular PhysiologyOct 25

Does the Exercise Delay Age-Related Cognitive Impairment: Conversation Between White Matter, Myelin Sheath, and Oligodendrocyte During Exercise?

ReviewExercise

Paper

Neural Regeneration ResearchOct 25

O-linked β-N-acetylglucosamine homeostasis in brain health and disease: From physiology to neurodevelopmental and neurodegenerative disorders

ReviewProteostasis

Paper

Journal of Alzheimer's DiseaseOct 25

Physical activity and brain aging in Sub-Saharan Africa: A scoping review of observational studies

Systematic review of observational studiesPopulations

Paper

Saturday, October 24

medRxivOct 24

Plasma eMTBR-tau as a marker of clinical stage and progression across the Alzheimer's disease continuum

NULISAseqTM Neuro 220 panel biomarker differences across the AD continuum Volcano plots compare A) MCI (n=228) with SCD (n=186), B) AD (n=22) with SCD, and C) AD with MCI (right).

Preprint: cohort study of 436 peopleAlzheimer's disease

Paper

medRxivOct 24

Parental dementia history linked to immune-cell shifts in midlife

An observational study of 1,204 middle-aged adults found no link between parental dementia history and faster aging on DNA-based measures or brain scans.An observational study of 1,204 middle-aged adults found no link between parental dementia history and faster aging on DNA-based measures or brain scans.

Epigenetic aging and peripheral immune cell composition in individuals with and without parental history of dementia.

Preprint: cross-sectional study of 1,204 peopleBlood and immune system

Paper

Journal of Alzheimer's DiseaseOct 24

A putative iron-related evolving framework in Alzheimer's disease: From iron dyshomeostasis and ferro-aging to ferroptosis

ReviewFerroptosis

Paper

Friday, October 23

GeroScienceOct 23

Advanced brain age and longitudinal cognitive decline in healthy older adults

Cohort study of 4,606 peopleBiomarkers

Paper

BrainOct 23

TMEM106B risk converges on C-terminal fragment homeostasis: genetics, mechanisms and therapy

ReviewProteostasis

Paper

Metabolic Brain DiseaseOct 23

Metabolic Dyshomeostasis, neuroinflammation, and glymphatic clearance deficits as convergent drivers of Alzheimer's disease: an exposome-based conceptual framework for prevention

ReviewOxidative phosphorylation

Paper

Cell Death & DiseaseOct 23

Apelin-13 prevented an aging-related state in lab-grown nerve cells

Experiments in human nerve-cell models found that apelin-13 restored a cellular recycling process disrupted by D-galactose, a sugar used to induce aging-like changes.Experiments in human nerve-cell models found that apelin-13 restored a cellular recycling process disrupted by D-galactose, a sugar used to induce aging-like changes.