Major depressive disorder
Disease1 paper2 findings
- Humans1
Associations
2DunedinPACE
upin humans1OR 1.46
1 study
DunedinPACE
upin humans1OR 1.46
DunedinPACE is associated with Major depressive disorder in humans (OR = 1.46, 95% CI = 1.15 – 1.85).
Humans6 months after trauma6 monthsn = 660
Accelerated epigenetic aging predicts major depression and brain changes after trauma · medRxiv · 28 Sep 2026 · Preprint
GrimAge
upin humans1OR 1.44
1 study
GrimAge
upin humans1OR 1.44
GrimAge is associated with Major depressive disorder in humans (OR = 1.44, 95% CI = 1.12 – 1.85).
Humans6 months after trauma6 monthsn = 660
Accelerated epigenetic aging predicts major depression and brain changes after trauma · medRxiv · 28 Sep 2026 · Preprint
Latest
1Accelerated epigenetic aging predicts major depression and brain changes after trauma
Emergency department measurements of GrimAge and DunedinPACE biological aging markers tracked subsequent depressive symptoms and neural connectivity shifts in adults over 35.
medRxiv · Navarro-Flores A et al.