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An observational study of 46,843 UK Biobank participants linked higher genetic risk and unhealthy lifestyles to faster aging estimated from brain scans.An observational study of 46,843 UK Biobank participants linked higher genetic risk and unhealthy lifestyles to faster aging estimated from brain scans.
Experiments in mice at 12 and 18 months found different behavioral and memory changes in males and females exposed to prenatal stress.Experiments in mice at 12 and 18 months found different behavioral and memory changes in males and females exposed to prenatal stress.
In six-month-old mice with accelerated aging, ER272 was linked to better cognition and preserved markers of new brain cells in males, but showed limited effects in…In six-month-old mice with accelerated aging, ER272 was linked to better cognition and preserved markers of new brain cells in males, but showed limited effects in females.
In 86 adults, brain scans showed widespread white matter changes, while older people relied on different nerve pathways than younger adults for executive tasks.In 86 adults, brain scans showed widespread white matter changes, while older people relied on different nerve pathways than younger adults for executive tasks.
Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.
In an observational study of 2,796 adults, a multimodal brain-age model predicted chronological age with an average error of 3.45 years.In an observational study of 2,796 adults, a multimodal brain-age model predicted chronological age with an average error of 3.45 years.
Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.Tested on large-scale scan datasets, the computational framework combined regional brain shape changes to track aging speed and spot abnormal patterns in disease.
In people with an average age of 68 at risk of dementia, six of ten metabolite groups in blood plasma tracked with frailty scores.In people with an average age of 68 at risk of dementia, six of ten metabolite groups in blood plasma tracked with frailty scores.
Rare-variant carriers had a 58% smaller age-related reduction in one brain region's glucose use than typical carriers of an inherited Alzheimer's variant.Rare-variant carriers had a 58% smaller age-related reduction in one brain region's glucose use than typical carriers of an inherited Alzheimer's variant.
A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.
In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.In a 104-person trial sub-study, rising levels of gut-produced urolithins tracked with preserved cortical thickness over two years in 55 older adults eating walnuts.
Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell signaling and increased…Experiments in 15-month-old mice with reduced Nipsnap1, a protein involved in cell maintenance, found reduced gene activity linked to nerve-cell signaling and increased activity linked to inflammation.
The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.The gap between scan-estimated and actual age exceeded age-matched controls by 7.64 years in schizophrenia and 7.61 years in frontotemporal dementia.
An observational study followed brain scans from 4,276 middle-aged and older adults, linking higher exposure to particle pollution with faster gray matter loss.An observational study followed brain scans from 4,276 middle-aged and older adults, linking higher exposure to particle pollution with faster gray matter loss.
In a cross-sectional study of 6,690 adults, healthy plant-rich eating patterns and specific foods like fruits and vegetables tracked with lower rates of hyposmia.In a cross-sectional study of 6,690 adults, healthy plant-rich eating patterns and specific foods like fruits and vegetables tracked with lower rates of hyposmia.
In 137 aging adults tracked across one year, changes in estradiol and testosterone showed opposing associations with cerebellar subregion volumes in men and women.In 137 aging adults tracked across one year, changes in estradiol and testosterone showed opposing associations with cerebellar subregion volumes in men and women.
