There are 21 papers on IL6 in aging research: 6 observational studies in people, 6 in animals, 5 in cells, 3 reviews.
3 new papers in 30 daysSee all 21
“While the CC G174C IL6, TT C677T MTHFR genotype is probably protective against the development of sarcopenia.”
None of its findings points the other way.
- 5 independent labs in 4 countries
- 9 trials
- Funders: Austrian Research Promotion Agency and others
- 3 of 6 findings with company ties
- 9 of 9 trials sponsored by developers of drugs aimed at it
- Humans6
- Animals6
- Cells5
- In silico1
Interventions
1Advanced age
downin E. caballus1
1 study
Advanced age
downin E. caballus1
Advanced age decreases IL6 in E. caballus (whole blood stimulated with LPS).
“expressions of IL-8 and IL-6 in whole blood samples stimulated for 6 h with 0.01 μg/mL LPS and for 2 h with 1 μg/mL LPS, respectively, were significantly lower”
Animalswhole blood stimulated with LPSwhole blood1 μg/mL LPS2 hn = 7
Veterinary immunology and immunopathology
Effects
3Catabolism
upin reviews1
1 study
Catabolism
upin reviews1
IL6 increases catabolism in cachexia.
“emphasizing how identical mediators, including interleukin-6, can promote either catabolism or adaptation depending on context.”
Reviewin cachexia
Muscle-immune metabolic crosstalk: shared pathways in cachexia and exercise
Current opinion in biotechnology
Mesenchymal stem cell expansion
downin human cells1
1 study
Mesenchymal stem cell expansion
downin human cells1
IL6 decreases mesenchymal stem cell expansion in human cells (shown by inhibition in absence of WNT3A).
“Inhibition of those mediators by interference with NF-κB or interleukin 6 signalling reduced paracrine senescence in absence of WNT3A and promoted the expansion of MSCs”
Cellsshown by inhibition in absence of WNT3A
Cellular and molecular life sciences : CMLS
paracrine senescence
upin human cells1
1 study
paracrine senescence
upin human cells1
IL6 increases paracrine senescence in human cells (shown by inhibition in absence of WNT3A).
“Inhibition of those mediators by interference with NF-κB or interleukin 6 signalling reduced paracrine senescence in absence of WNT3A”
Cellsshown by inhibition in absence of WNT3A
Cellular and molecular life sciences : CMLS
Upstream
2Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
Cellular senescence decreases IL6 in human cells.
“the pro-inflammatory cytokines IL6 and CCL2 were downregulated in senescent astrocytes relative to proliferating cells, opposite to their behavior in fibroblasts”
Cellssenescent astrocytes relative to proliferating astrocytes; opposite direction in fibroblastsastrocytes
Characterization of Cellular Senescence in Primary Human Astrocytes
bioRxiv : the preprint server for biologyPreprint
GRSF1
downin human cells1
1 study
GRSF1
downin human cells1
GRSF1 decreases IL6 in human cells (shown by knockout in M(IL-4 + IL-13) macrophages).
“macrophages differentiated from GRSF1-deficient THP-1 monocytes, particularly M(IL-4 + IL-13) macrophages, displayed elevated IL6 mRNA expression levels and TNF-α secretion”
Cellsshown by knockout in M(IL-4 + IL-13) macrophagesmacrophage
Scientific reports
Associations
1Sarcopenia
downin humans1
1 study
Sarcopenia
downin humans1
IL6 is associated with sarcopenia in humans (CC G174C genotype; the reported group distribution conflicts with the conclusion).
“While the CC G174C IL6, TT C677T MTHFR genotype is probably protective against the development of sarcopenia.”
HumansCC G174C genotype; the reported group distribution conflicts with the conclusionfemalesn = 67
The role of the genetic factor in the development of sarcopenia
Clinical Medicine (Russian Journal)