White matter hyperintensities

Biomarker2 papers3 findings

  • Humans2

Effects

3

Hippocampal volume

no changein humans1

1 study
  1. White matter hyperintensities have no effect on hippocampal volume in humans.

    Humanshippocampus9 yearsn = 104

    White matter damage is linked to greater cortical thinning in men · Human brain mapping · 29 Sep 2026

Hippocampal volume →

Cortical area

upin humans1

1 study
  1. White matter hyperintensities increase cortical area in humans.

    Humanscortex9 yearsmalesn = 104

    White matter damage is linked to greater cortical thinning in men · Human brain mapping · 29 Sep 2026

Cortical area →

Cortical thickness

downin humans1

1 study
  1. White matter hyperintensities decrease cortical thickness in humans.

    Humanscortex9 yearsn = 104

    White matter damage is linked to greater cortical thinning in men · Human brain mapping · 29 Sep 2026

Cortical thickness →

Latest

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Alzheimer's Research & TherapyHumans

Education links to better cognition independent of brain pathology

Across two aging cohorts spanning normal cognition to mild Alzheimer’s disease, higher education tracked with better cognitive performance even after…Across two aging cohorts spanning normal cognition to mild Alzheimer’s disease, higher education tracked with better cognitive performance even after adjusting for multimodal brain pathology.

Translational Stroke ResearchHumans

Plasma CXCL10 links to higher stroke risk in older adults

Each 1-standard deviation higher CXCL10 was linked to 20% greater stroke risk over a median follow-up of 14 years.Each 1-standard deviation higher CXCL10 was linked to 20% greater stroke risk over a median follow-up of 14 years.

medRxivHumansPreprint

Brain small vessel disease links to stroke and mortality risk

Compared with a zero score, participants with cerebral small vessel disease scores of 1 and 2 had hazard ratios of 1.48 and 1.52 for adverse events.Compared with a zero score, participants with cerebral small vessel disease scores of 1 and 2 had hazard ratios of 1.48 and 1.52 for adverse events.

medRxivHumansPreprint

Brain MRI predicts conversion to mild cognitive impairment

Adding brain MRI to baseline traits predicted conversion from subjective decline to mild impairment with an AUC of 0.923 at five years.Adding brain MRI to baseline traits predicted conversion from subjective decline to mild impairment with an AUC of 0.923 at five years.

Neurology GeneticsHumans

GLP-1 receptor agonists link to lower stroke and Alzheimer risk

A cross-ancestry Mendelian randomization study of up to 1,812,017 individuals linked genetically proxied GLP-1 receptor agonist exposure to reduced…A cross-ancestry Mendelian randomization study of up to 1,812,017 individuals linked genetically proxied GLP-1 receptor agonist exposure to reduced risk of stroke and Alzheimer disease.

bioRxivHumansPreprint

DASH diet across adulthood links to better late-life brain health

In 892 older adults, brain measures mediated 12.3% and 12.5% of the links between DASH diet adherence and late-life verbal memory.In 892 older adults, brain measures mediated 12.3% and 12.5% of the links between DASH diet adherence and late-life verbal memory.

Human Brain MappingHumans

White matter damage is linked to greater cortical thinning in men

In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical…In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical area in men.