CCHa1

1. CCHa1 extends lifespan in flies.

   “impairment of the CCHa1-mediated gut-enteric neuronal axis results in ammonia accumulation and a shortened lifespan under HPD conditions.”

   Model organismsunder high-protein diet conditions, shown by impairment of the CCHa1-mediated gut-enteric neuronal axis

   A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster

   Nature communications·30 Dec 2024

1. CCHa1 decreases ammonia accumulation in flies.

   “impairment of the CCHa1-mediated gut-enteric neuronal axis results in ammonia accumulation and a shortened lifespan under HPD conditions.”

   Model organismsunder high-protein diet conditions, shown by impairment of the CCHa1-mediated gut-enteric neuronal axis

   A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster

   Nature communications·30 Dec 2024

More on Ammonia accumulation

1. CCHa1 decreases protein overconsumption in flies.

   “the peptide hormone CCHamide1 (CCHa1), secreted by enteroendocrine cells in response to a high-protein diet (HPD), is vital for suppressing overconsumption of protein.”

   Model organismshigh-protein diet

   A high-protein diet-responsive gut hormone regulates behavioral and metabolic optimization in Drosophila melanogaster

   Nature communications·30 Dec 2024