Transcriptomic age
Biomarker2 papers2 findings
- Animals1
- Cells1
Interventions
2Simulated microgravity
upin human cells1
1 study
Simulated microgravity
upin human cells1
Simulated microgravity increases transcriptomic age in human cells.
“accompanied by higher transcriptomic-age estimates in neural and cardiac models”
Cellsin rotating-wall vesselsrotating-wall vesselscardiac organoids24 hours
Simulated microgravity increases transcriptomic age in human organoids · bioRxiv · 1 Oct 2026 · Preprint
NKX2-5 overexpression
downin mouse cells1
1 study
NKX2-5 overexpression
downin mouse cells1
NKX2-5 overexpression decreases transcriptomic age in mouse cells.
Cells
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice · bioRxiv · 30 Sep 2026 · Preprint
Latest
3Simulated microgravity increases transcriptomic age in human organoids
Culturing human neural, cardiac, and tonsil models in rotating-wall vessels for 24 hours also shifted contraction dynamics and immune gene expression.
bioRxiv · Mu W-C et al.
Engineered cardiac transcription factor restores vision and reduces frailty in aging mice
A genome-scale screen in retinal cells identified NKX2-5 variants that conferred oxidative resilience and improved physical function without detectable toxicity.
bioRxiv · Lu YRR et al.
Blood and facial photos track organ aging and senescence scores in humans
Researchers used transcriptomic models, DNA methylation, and images across multiple human cohorts to infer tissue-specific biological age and hallmark burdens.
bioRxiv · Schneider KL et al.