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Muscle disuse

Exposure

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Australian Government and others
  • Humans1

Outcomes

3

Muscle recovery

downin reviews1

1 study

  1. Muscle disuse impairs muscle recovery.

    “compared to adult limb muscles, aged limb muscles respond differently and have blunted recovery after disuse.”

    Review

    Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction

    Experimental physiologyJul 10, 2025

Muscle function

downin reviews1

1 study

  1. Muscle disuse impairs muscle function.

    “suppression of lysosomal activity contributes to the accumulation of defective mitochondria and other cellular debris, impairing muscle function.”

    Reviewmuscle disuse

    Regulation of lysosomes in skeletal muscle during exercise, disuse and aging

    Free radical biology & medicineSep 25, 2024

Transcriptomic age

upin humans1

1 study

  1. Muscle disuse increases transcriptomic age in humans.

    “the transcriptome shifted toward an older state after forced muscle disuse”

    Human trialskeletal muscle

    Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

    Aging cellMay 2, 2023

More on Transcriptomic age

Funding

2 grants since 2021

National Institute on AgingUS$980.7kJapan Society for the Promotion of ScienceJP¥4m

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