InterventionPartial reprogramming
3 papers5 findings
Alveolar progenitor-like state
upin human cells1
Chemical reprogramming induces alveolar progenitor-like state in human cells.
“enables efficient conversion of adult human AT2 cells into a highly expandable alveolar progenitor-like state”
Cellsalveolar type 2 cell
Adult human lung cells became expandable precursor-like cells
Advanced science (Weinheim, Baden-Wurttemberg, Germany)4 Oct 2026
Uniform CD13-low cell populations
upin human cells1
Chemical reprogramming induces uniform CD13-low cell populations in human cells.
“Chemical reprogramming produced uniform CD13-low populations without pluripotency marker induction.”
Cellshuman-optimized protocolfibroblast
bioRxiv (Cold Spring Harbor Laboratory)1 Dec 2025Preprint
Age-associated gene expression
downin human cells1
Chemical reprogramming decreases age-associated gene expression in human cells.
“Both reprogramming methods reduced senescence, mitochondrial ROS, and age-associated gene expression, with chemical reprogramming matching or exceeding OSKM efficacy.”
Cellsprogerin-induced aged fibroblasts and primary fibroblasts from donors over 85human-optimized protocolfibroblast
bioRxiv (Cold Spring Harbor Laboratory)1 Dec 2025Preprint
Mitochondrial ROS
downin human cells1
Chemical reprogramming decreases mitochondrial ROS in human cells.
“Both reprogramming methods reduced senescence, mitochondrial ROS, and age-associated gene expression, with chemical reprogramming matching or exceeding OSKM efficacy.”
Cellsprogerin-induced aged fibroblasts and primary fibroblasts from donors over 85human-optimized protocolfibroblast
bioRxiv (Cold Spring Harbor Laboratory)1 Dec 2025Preprint
Cellular senescence
downin human cells1
Chemical reprogramming decreases cellular senescence in human cells.
“chemical reprogramming lowered senescence during active treatment.”
Cellshuman-optimized protocolfibroblastduring active treatment
bioRxiv (Cold Spring Harbor Laboratory)1 Dec 2025Preprint
Experiments with adult human lung cells produced cells that could multiply extensively and form three-dimensional models resembling mature lung air sacs.Experiments with adult human lung cells produced cells that could multiply extensively and form three-dimensional models resembling mature lung air sacs.