Mitochonic ACID-5
Intervention1 paper4 findingsPubChem 76070959ChEBI 234581
A preprint reports that Mitochonic ACID-5 improves survival and lowers brain transcriptomic age in a Gaucher disease mouse model, while inhibiting NLRP3 inflammasome and cGAS–STING signalling in that model and patient-derived iPSC microglia.
- Animals1
Outcomes
4NLRP3 inflammasome
downin mice1Very low certainty
1 study
NLRP3 inflammasome
downin mice1Very low certainty
Mitochonic ACID-5 inhibits NLRP3 inflammasome in mice.
Animalsin a Gaucher disease mouse model and patient-derived iPSC microglia
MA-5 attenuates disease-associated transcriptomic aging and pathological microglial states in Gaucher disease · Research square · 14 Sep 2026 · Preprint
cGAS–STING signalling
downin mice1Very low certainty
1 study
cGAS–STING signalling
downin mice1Very low certainty
Mitochonic ACID-5 inhibits cGAS–STING signalling in mice.
Animalsin a Gaucher disease mouse model and patient-derived iPSC microglia
MA-5 attenuates disease-associated transcriptomic aging and pathological microglial states in Gaucher disease · Research square · 14 Sep 2026 · Preprint
Transcriptomic age
downin mice1Very low certainty
1 study
Transcriptomic age
downin mice1Very low certainty
Mitochonic ACID-5 decreases transcriptomic age in mice.
Animalsin a Gaucher disease mouse modelbrain
MA-5 attenuates disease-associated transcriptomic aging and pathological microglial states in Gaucher disease · Research square · 14 Sep 2026 · Preprint
Survival
upin mice1Very low certainty
1 study
Survival
upin mice1Very low certainty
Mitochonic ACID-5 improves survival in mice.
Animalsin a Gaucher disease mouse model
MA-5 attenuates disease-associated transcriptomic aging and pathological microglial states in Gaucher disease · Research square · 14 Sep 2026 · Preprint