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Mitochondria

Biomarker

2 papers2 findings

  • Animals2

Interventions

1

Osmotic challenge

downin mice1

1 study

  1. Osmotic challenge decreases mitochondria in mice.

    “did show a significant reduction in the number of mitochondria in the old group, particularly during the osmotic challenge period”

    Animalsduring osmotic challengesupraoptic nucleusmales

    The effect of osmotic challenge and subsequent rehydration on the aging hypothalamo-neurohypophyseal system. A quantitative morphological study of the supraoptic nucleus

    Mechanisms of ageing and development1 Aug 1984

More on Osmotic challenge

Upstream

1

APP

downin mice1

1 study

  1. APP decreases mitochondria in mice.

    “Ultrastructural analysis of excitatory presynaptic mitochondria revealed fewer mitochondria in Dutch mouse presynaptic termini.”

    Animalsin Dutch mice vs WTbrain

    Visualization of accumulated, physiologically generated Dutch‐type Aβ oligomers associated with impaired learning and abnormal presynaptic physiology but no detectable neuroinflammation

    AAIC 2025 abstract23 Dec 2025

More on APP

Funding

47 grants since 2016

Japan Society for the Promotion of ScienceJP¥61.2mAmerican Heart AssociationUS$784.7kAgencia Nacional de Investigación y DesarrolloCLP 701.1k

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Aging Cell

High-fat diet effects persist in lab-grown rat liver structures

Experiments using liver structures grown from high-fat-fed male rats found persistent changes resembling senescence, a state in which cells stop dividing.Experiments using liver structures grown from high-fat-fed male rats found persistent changes resembling senescence, a state in which cells stop dividing.

Experiments in liver organoids from male rats, against organoids from control-fed ratsMechanisms

Limit: Organoid cell composition was unknown; persistence was demonstrated in populations, not individual cells

Paper
Aging Cell

Mitochondrial DNA and age shape retinal changes in mice

Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signalling.Experiments in mice with matching nuclear DNA but different mitochondrial DNA linked aging to changes in retinal energy-producing proteins and immune signalling.

Experiments in male and female mice with differing mtDNA, against mice with C57 mtDNAMitochondrion

Limit: The mtDNA damage result lost significance when a potential outlier was excluded

Paper
Nature Metabolism

Linked metabolic disruptions halt division in human cells

An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the…An engineered bacterial enzyme reversed the growth arrest by expanding a pool of molecules used to build cellular components in human connective-tissue cells grown in the lab.

Experiments in primary human fibroblastsInterventions

Limit: Senescence features are a proxy for cellular ageing, not a direct measure of it

Paper
Developmental Cell

Two pathways in cells work together to amplify inflammation

Mitochondrial citrate metabolism drove inflammation through a pathway that acted independently of mitochondrial DNA-triggered immune signalling but cooperated with it to…Mitochondrial citrate metabolism drove inflammation through a pathway that acted independently of mitochondrial DNA-triggered immune signalling but cooperated with it to amplify inflammation.

Study of senescent cellsInflammation

Limit: No experimental details or numerical results are provided to assess the claimed pathway cooperation

Paper

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