Mitochondrial complex I activity

Biomarker

3 papers2 findings

Animals2
Cells1

Upstream

APP

downin mice1

1 study

APP decreases mitochondrial complex I activity in mice.
“Mitochondrial complex I activity was reduced in 12‐ but not 7‐mo‐old Dutch vs WT mice.”
Animalsin Dutch mice vs WTbrain
Visualization of accumulated, physiologically generated Dutch‐type Aβ oligomers associated with impaired learning and abnormal presynaptic physiology but no detectable neuroinflammation
AAIC 2025 abstract23 Dec 2025

Funding

3 grants since 2017

National Institute on AgingUS$7mAlzheimer's Drug Discovery FoundationUS$600kAmerican Heart AssociationUS$155.3k

Latest

7 in 12 months

Aging29 Sep

Hypomagnetic fields modulate lifespan, physical ability and mitochondrial metabolism in a Pink1 model of neurodegeneration

Experiments in fliesOxidative phosphorylation

Paper

Journal of Environmental Sciences1 Sep

Simultaneously PYCR-1 and ALH-6 inhibition exacerbates 6-PPD quinone toxicity via disrupting proline and glutamate metabolisms and activating insulin signals in Caenorhabditis elegans

Experiments in wormsAmino acid metabolism

Paper

Alzheimer's & Dementia9 Jun

Endogenously generated Dutch-type Aβ non-fibrillar aggregates dysregulate presynaptic neurotransmission in the absence of detectable inflammation

Experiments in animalsMechanisms

Paper

Journal of Hazardous Materials28 Feb

Uranium exposure induces osteopenia via mitochondrial dysfunction-driven senescence in bone marrow mesenchymal stem cells

Experiments in miceOxidative phosphorylation

Paper

Animals27 Feb

Nicotinamide Mononucleotide Modulates Endothelin-1 via NR4A1 and Histone Modifications in Canine Intestinal Epithelial Cells

Experiments in cellsNicotinamide mononucleotide

Paper

AAIC 2025 Abstract24 Dec

Visualization of accumulated, physiologically generated Dutch‐type Aβ oligomers associated with impaired learning and abnormal presynaptic physiology but no detectable neuroinflammation

Experiments in miceInflammation

Paper

AAIC 2025 Abstract23 Dec

Visualization of accumulated, physiologically generated Dutch‐type Aβ oligomers associated with impaired learning and abnormal presynaptic physiology but no detectable neuroinflammation

Experiments in miceInflammation

Paper

Journal of Pharmacological Sciences16 Nov

Effects of imeglimin on mitochondrial functions and ischemic brain damage in young and aging rats

Experiments in ratsInterventions

Paper

EMBO Reports18 Mar

Developmental mitochondrial complex I activity determines lifespan

Experiments in model organismsMechanisms

Paper

Translational Medicine of Aging1 Jan

Dietary duration and composition differentially influence mitochondrial activity and gene expression in a tissue-specific manner in aged rats

Experiments in animalsInterventions

Paper

Mitochondrial complex I activity

Upstream

Funding

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