MechanismsAnimals
Visualization of accumulated, physiologically generated Dutch‐type Aβ oligomers associated with impaired learning and abnormal presynaptic physiology but no detectable neuroinflammation
AAIC 2025 Abstract
Abstract
Background: Studies of Alzheimer's disease have demonstrated that cognitive decline fails to correlate with fibrillar Aβ burden. Method: We created a transgenic mouse overexpressing Dutch mutant hAPP (APPE693Q) driven by a pan‐neuronal Thy1 promoter.
The paper
Sam E Gandy, Emilie L. Castranio, Merina Varghese, Michelle E. Ehrlich
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Elentina K. Argyrousi, Kuldeep Kumar Tripathi, Linda Söderberg, Erin R. Bresnahan, David Lerner, Francesca Garretti, H Z Zhang, Jonathan Van de Loo, B. T. Teunissen, Ronan Talty, Efrat Levy, Minghui Wang, Bin Zhang, Lars Lannfelt, Charles G. Glabe, William D. Lubell, Brigitte Guérin, Shai Rahimipour, Dara L. Dickstein, Ottavio Arancio,James J. Peters VA Medical Center · Icahn School of Medicine at Mount Sinai
AAIC 2025 Abstract · 23 Dec 2025 · CC BY
Presented at AAIC 2025
