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Plastic leachate

Intervention

2 papers study it6 findings

Across all fields, 2 papers: none in people yet, 2 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Department of Science and Technology, Republic of the Philippines and 6 more
  • Model organisms2

Outcomes

6

Response to mechanical stimuli

no changein worms1

1 study

  1. Plastic leachate has no effect on response to mechanical stimuli in worms.

    “No changes were observed in the ability of the C. elegans to respond to mechanical stimuli.”

    Model organisms

    Leachates from plastics and bioplastics reduce lifespan, decrease locomotion, and induce neurotoxicity in Caenorhabditis elegans

    Environmental pollution (Barking, Essex : 1987)

Locomotion

downin worms1

1 study

  1. Plastic leachate impairs locomotion in worms (8%-34%).

    “Leachates from plastics decreased locomotion in C. elegans more compared to leachates from bioplastics: by 8%-34% for plastics and by 11%-24% for bioplastics.”

    Model organisms

    Leachates from plastics and bioplastics reduce lifespan, decrease locomotion, and induce neurotoxicity in Caenorhabditis elegans

    Environmental pollution (Barking, Essex : 1987)

Lifespan

downin worms1

1 study

  1. Plastic leachate shortens lifespan in worms (6%-15%).

    “by 7%-31% for bioplastics and by 6%-15% for plastics.”

    Model organisms

    Leachates from plastics and bioplastics reduce lifespan, decrease locomotion, and induce neurotoxicity in Caenorhabditis elegans

    Environmental pollution (Barking, Essex : 1987)

Tumor growth

upin flies1

1 study

  1. Plastic leachate increases tumor growth in flies.

    “potentiating tumor growth and metastatic behavior ofRasV12 clones”

    Model organismsRasV12 clones

    Assessing genotoxic effects of plastic leachates in Drosophila melanogaster

    Chemosphere

Transposable element activity

upin flies1

1 study

  1. Plastic leachate activates transposable element activity in flies.

    “exposure to plastic leachates induces chromosomal abnormalities and transposable element (TE) activation in neural tissues”

    Model organismsneural tissues

    Assessing genotoxic effects of plastic leachates in Drosophila melanogaster

    Chemosphere

More on Transposable element activity

Longevity

no changein flies1

1 study

  1. Plastic leachate has no effect on longevity in flies.

    “developmental times and longevity remain largely unaffected”

    Model organisms

    Assessing genotoxic effects of plastic leachates in Drosophila melanogaster

    Chemosphere

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