Systemic immune-inflammation index

1. Systemic immune-inflammation index predicts cardiovascular mortality in humans (HR 1.21 (95% CI 1.12-1.32)).

   “1.21 (1.12-1.32) for SII”

   Humans11.4 yearsn = 15,141

   Limited incremental value of three complete-blood-count inflammatory indices for cardiovascular mortality: a development and external validation study in 30,533 US adults · medRxiv · 2 Oct 2026 · Preprint

1. Systemic immune-inflammation index is associated with cardiometabolic multimorbidity in humans.

   Humansfully adjusted model

   Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity · Brain, behavior, & immunity - health · 19 Sep 2026

Cardiometabolic multimorbidity →

1. Systemic immune-inflammation index predicts 30-day mortality in humans.

   “CCI, CFS, and ln(SII) were each independently associated with mortality in the integrated multivariable model”

   Humansn = 326

   Integrated Risk Stratification Using Comorbidity Burden, Frailty, and Systemic Inflammation to Predict 30-Day Mortality in Older Emergency Department Patients: A Prospective Cohort Study · Journal of clinical medicine · 8 Sep 2026