Multimodal prehabilitation

1. Multimodal prehabilitation has no effect on long-term care dependency in humans (absolute between-group difference in change over time of -0·1 (95% CI -0·25 to 0·07; p=0·26)).

   Human trialolder patients with frailty or prefrailty undergoing elective surgery3 weeksn = 1,199

   Supervised multimodal prehabilitation of older patients with frailty or prefrailty before elective surgery: a multicentre randomised controlled outcome assessor-blinded trial · The lancet. Healthy longevity · 15 Sep 2026

1. Multimodal prehabilitation improves physical function in humans.

   Human trialprefrail and frail older men undergoing radical prostatectomymalesn = 80

   Short-term home-based multimodal prehabilitation for perioperative functional recovery in prefrail and frail older men undergoing radical prostatectomy: a randomized controlled trial · BMC geriatrics · 24 Jul 2026

1. Multimodal prehabilitation improves 6-minute walk test in humans (30.82 m (95% CI, 25.32 to 36.33; P < 0.001)).

   Human trialprefrail and frail older men undergoing radical prostatectomymedian duration of 12 daysmalesn = 80

   Short-term home-based multimodal prehabilitation for perioperative functional recovery in prefrail and frail older men undergoing radical prostatectomy: a randomized controlled trial · BMC geriatrics · 24 Jul 2026

6-minute walk test →