Proteomics
Method6 papers
- Humans3
- Animals2
Latest
6An 11-protein blood score tracks incident dementia risk
In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard…In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard deviation increase.
Proteomic and bioinformatic profiling of the aging mouse heart-diaphragm system
Blood proteins improve early cardiometabolic risk prediction
In 43,709 adults with early-stage disease, outcome-specific proteomic signatures improved clinical risk discrimination across 11 incident outcomes…In 43,709 adults with early-stage disease, outcome-specific proteomic signatures improved clinical risk discrimination across 11 incident outcomes, boosting C-index values by 0.024 to 0.070.
Aging rhesus macaques display distinct fluid proteomic signatures of senescence and neuropathology
Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.