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Atole

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Human trial1

Outcomes

3

GrimAge

downin humans1

1 study

  1. Atole decreases GrimAge in humans (-0.85 y, 95% CI -1.53, -0.11).

    “and GrimAge acceleration (-0.85 y, 95% CI -1.53, -0.11) compared to other exposures”

    Human trialduring first 1,000 days of lifen = 1,095

    Early-life nutrition supplementation and epigenetic age in middle-adulthood among Guatemalan adults

    bioRxiv : the preprint server for biology29 Sep 2025Preprint

More on GrimAge

PhenoAge

downin humans1

1 study

  1. Atole decreases PhenoAge in humans (-1.91 y, 95% CI -3.43, -0.39).

    “PhenoAge acceleration (- 1.91 y, 95% CI -3.43, -0.39)”

    Human trialduring first 1,000 days of lifen = 1,095

    Early-life nutrition supplementation and epigenetic age in middle-adulthood among Guatemalan adults

    bioRxiv : the preprint server for biology29 Sep 2025Preprint

More on PhenoAge

DunedinPACE

downin humans1

1 study

  1. Atole decreases DunedinPACE in humans (-0.03, 95% CI -0.06, -0.004).

    “exposure to atole during any of the first 1,000-day period was associated with lower DunedinPACE (-0.03, 95% CI -0.06, -0.004)”

    Human trialduring first 1,000 days of lifen = 1,095

    Early-life nutrition supplementation and epigenetic age in middle-adulthood among Guatemalan adults

    bioRxiv : the preprint server for biology29 Sep 2025Preprint

More on DunedinPACE

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