Constipation

1. Constipation has no effect on comprehensive frailty in humans.

   Humans

   Defecation Frequency, Stool Form, and Comprehensive Frailty in Community-Dwelling Older Adults: A Cross-Sectional Study · Research Square · 2 Sep 2026 · Preprint

1. Depression mediates constipation in silico (19.062% mediated, indirect β = 0.067, 95% CI 0.005–0.143).

   In silicomediating the genetic effect of frailty on constipation

   Frailty and constipation in older adults and the mediating role of depression: cross-sectional evidence from NHANES 2005–2010 and genetic evidence from Mendelian randomization · Research Square · 20 Aug 2026 · Preprint

Depression →

1. Frailty index raises the risk of constipation in silico (OR 1.420, 95% CI 1.030–1.958).

   In silicogenetically predicted (Mendelian randomization)

   Frailty and constipation in older adults and the mediating role of depression: cross-sectional evidence from NHANES 2005–2010 and genetic evidence from Mendelian randomization · Research Square · 20 Aug 2026 · Preprint

2. Frailty index is associated with constipation in humans (OR 1.363, 95% CI 1.009–1.841).

   Humansfully adjustedn = 4,333

   Frailty and constipation in older adults and the mediating role of depression: cross-sectional evidence from NHANES 2005–2010 and genetic evidence from Mendelian randomization · Research Square · 20 Aug 2026 · Preprint

Frailty index →

1. Depression raises the risk of constipation in silico (OR 1.096, 95% CI 1.008–1.192).

   In silicogenetically predicted (Mendelian randomization)

   Frailty and constipation in older adults and the mediating role of depression: cross-sectional evidence from NHANES 2005–2010 and genetic evidence from Mendelian randomization · Research Square · 20 Aug 2026 · Preprint

Depression →