Genome instability

Biomarker

2 papers1 finding

  • Cells2

Interventions

1

Aav-centenarian SIRT6

downin human cells1

1 study
  1. Aav-centenarian SIRT6 decreases genome instability in human cells.

    “AAV)-mediated delivery of centenarian SIRT6 or pharmacological activation of SIRT6 using fucoidan from Fucus vesiculosus (Fucoidan-FV) partially attenuated aging-associated molecular defects”

    Cellsin progeria fibroblasts

    Centenarian SIRT6 variants elevate SIRT6 protein and enhance cellular senescence resistance

    Research square19 Jun 2026Preprint

More on Aav-centenarian SIRT6

Latest

Nov 2025: 11Dec 2025: 10Jan 2026: 18Feb 2026: 17Mar 2026: 17Apr 2026: 15May 2026: 11Jun 2026: 19Jul 2026: 17Aug 2026: 26Sep 2026: 13Oct 2026: 9183 in 12 months
Journal of Biochemical and Molecular Toxicology

Diesel-derived chemical triggers scarring signals in kidney cells

Experiments in kidney cells grown in the lab found that a diesel exhaust breakdown product caused lasting DNA damage and signals that activated connective-tissue cells.Experiments in kidney cells grown in the lab found that a diesel exhaust breakdown product caused lasting DNA damage and signals that activated connective-tissue cells.

Experiments in cellsKidney