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Enzymes

Papers on enzymes

6,700 papers162 new in 30 days

Saturday, October 17

Friday, October 16

Molecular & Cellular Proteomics

Cell-derived particles improved heart function in some aged mice

Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.Benefits were limited in mice lacking part of an energy-sensing enzyme; researchers compared treated aged mice with untreated young and aged mice.

Mouse studyInterventions
Paper

Thursday, October 15

Nature Aging

Suppressing a stem cell enzyme improved cognition in aging mice

Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.Experiments in aged mice found that suppressing a brain stem cell enzyme restored the function of circuits that restrain nerve cell activity.

Mouse studyMechanisms
Paper
medRxiv

Related blood pressure drugs linked to differing dementia risks

Compared with lisinopril, the drugs collectively had a dementia hazard ratio of 0.86, indicating a lower rate of new diagnoses over follow-up.Compared with lisinopril, the drugs collectively had a dementia hazard ratio of 0.86, indicating a lower rate of new diagnoses over follow-up.

Primary Outcome in Between-Class Comparisons of ARBs vs Lisinopril.
Preprint: cohort studyVascular dementia
Paper

Wednesday, October 14

Tuesday, October 13

Monday, October 12

bioRxiv

Chemical signals support regeneration in planarian flatworms

Researchers examined 51 genes for signaling molecules and found that 16 supported efficient regeneration, stem cell function or both in asexual planarian flatworms.Researchers examined 51 genes for signaling molecules and found that 16 supported efficient regeneration, stem cell function or both in asexual planarian flatworms.

Identification of planarian neuropeptide processing enzyme-encoding genes.
Preprint: experiments in model organismsMechanisms
Paper

Sunday, October 11

Saturday, October 10

Friday, October 9

bioRxiv

Aging alters eye tissue proteins differently in mice

In an experiment comparing 73-week-old mice with 8-week-old mice, aging changed 85 proteins in the retina and 272 in the supporting eye tissue.In an experiment comparing 73-week-old mice with 8-week-old mice, aging changed 85 proteins in the retina and 272 in the supporting eye tissue.

Quantitative proteomics workflow.
Preprint: experiments in miceEye
Paper

Thursday, October 8

eLife

Periodic red light exposure eases cellular aging in mice

In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.In aged mice, periodic red light exposure raised histone acetylation across tissues and reduced SIRT4 levels in skin cells to activate lipid metabolism.

Periodic red light irradiation treatment leads to increased H3K9ac and metabolism in skin tissues of a senescent mouse model.
Experiments in miceInterventions
Paper
Journal of Science and Medicine in Sport

Bands reduced liver fat in postmenopausal women with MASLD

In postmenopausal women with metabolic dysfunction-associated steatotic liver disease, an eight-week elastic band workout reduced a liver fat measure by 36.77 dB/m…In postmenopausal women with metabolic dysfunction-associated steatotic liver disease, an eight-week elastic band workout reduced a liver fat measure by 36.77 dB/m against controls.

Randomized trial in 52 peopleMetabolic dysfunction-associated steatotic liver disease
Paper
The American Journal of Cardiology

Drug class linked to fewer deaths or complications in kidney disease

The two-year combined outcome rate was 15.6% for sodium-glucose cotransporter 2 inhibitors versus 19.9% for renin-angiotensin system inhibitors, the comparison drug…The two-year combined outcome rate was 15.6% for sodium-glucose cotransporter 2 inhibitors versus 19.9% for renin-angiotensin system inhibitors, the comparison drug class.

Cohort study in peopleKidney
Paper