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In an experiment in mice with features of premature aging, a compound improved the performance of mitochondria, the energy-producing structures in muscle cells.In an experiment in mice with features of premature aging, a compound improved the performance of mitochondria, the energy-producing structures in muscle cells.
Experiments linked reduced bone formation to impaired sugar breakdown, while genetic changes that enhanced the process improved bone-forming cell function in aged mice.Experiments linked reduced bone formation to impaired sugar breakdown, while genetic changes that enhanced the process improved bone-forming cell function in aged mice.
In zebrafish experiments, loss of Gata4 stiffened material around cells, delayed tissue rebuilding and impaired recovery of movement after spinal cord injury.In zebrafish experiments, loss of Gata4 stiffened material around cells, delayed tissue rebuilding and impaired recovery of movement after spinal cord injury.
Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung cancer patient-derived…Pairing 390 nm irradiation with beta-galactosidase cleavage improved prodrug selectivity in senescence models and increased death in senescent lung cancer patient-derived organoids.
Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.Profiling conditioned media revealed that altered sphingolipid signaling reduces muscle stem cell pools in human cell cultures.
Patients taking an ARNI had an adjusted hazard ratio of 0.6 for osteoporosis compared with those taking an ACE inhibitor.Patients taking an ARNI had an adjusted hazard ratio of 0.6 for osteoporosis compared with those taking an ACE inhibitor.
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
In 4,543 adults, each standard deviation drop in amidation enzyme activity raised incident Alzheimer's risk with an adjusted hazard ratio of 2.30.In 4,543 adults, each standard deviation drop in amidation enzyme activity raised incident Alzheimer's risk with an adjusted hazard ratio of 2.30.
Incidence of all-cause dementia was 1.26 per 1000 person-years with RAS inhibitors versus 1.89 with calcium channel blockers (HR 0.68).Incidence of all-cause dementia was 1.26 per 1000 person-years with RAS inhibitors versus 1.89 with calcium channel blockers (HR 0.68).
In a randomized trial of 36 older stroke patients, a two-week combined regimen reduced reaction time more than either therapy alone.In a randomized trial of 36 older stroke patients, a two-week combined regimen reduced reaction time more than either therapy alone.
