Journal of Alzheimer's Disease Reports · Sep 6, 2026

Association between occlusal support, salivary amyloid-β42 levels, and cognitive function in older adults: A cross-sectional pilot study

By Juanita M, Talib B, Mude AH et al.

Background: Recent studies have highlighted a possible oral-systemic connection between decreased oral function, particularly reduced occlusal support, and cognitive decline. However, studies examining the relationship between occlusal support and peripheral biomarkers such as salivary amyloid-β42 (Aβ₄₂) remain limited. Objective: This study examined the association between occlusal support and cognitive decline by analyzing salivary Aβ₄₂ levels in older adults. Methods: A cross-sectional study was conducted among 62 participants categorized by occlusal support using the Eichner Index. Meanwhile, cognitive function and daily living abilities were assessed using the Mini-Mental State Examination (MMSE) and Lawton Instrumental Activities of Daily Living Scale (IADL). Salivary Aβ₄₂ levels were quantified using enzyme linked immunosorbent type assays. Results: Participants with reduced occlusal support exhibited lower MMSE and IADL scores, and higher salivary Aβ₄₂ levels (p < 0.05). Furthermore, salivary Aβ₄₂ concentrations increased across cognitive status categories and remained significant after adjustment for demographic, systemic, and oral health factors (ANCOVA p = 0.003). Multivariable regression identified unstimulated salivary flow rate as the strongest independent predictor of salivary Aβ₄₂ levels (β = -0.498, p < 0.001) Conclusions: Preserving occlusal support rather than solely focusing on replacing missing teeth may be relevant to cognitive health maintenance in older adults. These findings also support the potential role of salivary Aβ₄₂ as a non-invasive extracerebral biomarker of neurodegenerative disease, such as Alzheimer's disease.

doi.org/10.1177/25424823261478548Open accessPubMed 42877381Biomarkers