Chondrocyte senescence

2 papers

Animals1

Latest

38 in 12 months

Advanced Materials9 Oct

Self-renewing nanoparticles reduce friction and joint wear

The engineered particles cut friction over 90% compared with commercial hyaluronic acid and reversed chondrocyte senescence in lab models of osteoarthritis.The engineered particles cut friction over 90% compared with commercial hyaluronic acid and reversed chondrocyte senescence in lab models of osteoarthritis.

Experiments in animalsBones and joints

Journal of Orthopaedic Translation5 Oct

Low-intensity exercise eases age-related osteoarthritis in mice

In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect joints.In aged mice and cultured chondrocytes, swimming and a targeted PGC-1α-activating nanoparticle suppressed senescence and altered glycolysis to protect joints.

Experiments in miceExercise

Calcified Tissue International11 Sep

SERPINE1/PAI-1 in Skeletal Degeneration: A Proposed Context-Dependent Framework for Bone Remodeling Regulation

ReviewExtracellular matrix remodelling

Cell Reports28 Aug

Targeting pro-senescent PTGS2⁺ macrophages alleviates chondrocyte senescence and osteoarthritis progression

Experiments in miceOsteoarthritis

Experimental Gerontology13 Aug

Mitochondrial dysfunction as a key mediator of endplate chondrocyte senescence: emerging insights and targeted interventions

ReviewOxidative phosphorylation

Bioactive Materials9 Aug

Dual-modal antioxidant and epigenetic synergy attenuates the self-perpetuating senescence cycle in osteoarthritis

Experiments in miceOsteoarthritis

Osteoarthritis and Cartilage8 Aug

TL1A(TNFSF15)-ENO1 axis promotes osteoarthritis by disrupting redox homeostasis via the PI3K/AKT pathway

Experiments in micePI3K–AKT signalling

Molecular Biomedicine27 Mar

YTH N6-methyladenosine RNA binding protein 2 mediated m⁶A modification of circHIPK2 promotes cellular senescence and osteoarthritis progression by inhibiting autophagy

Experiments in miceOsteoarthritis

Cell Death & Disease26 Mar

cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis

Experiments in ratscGAS–STING signalling

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi16 Mar

Application of Kartogenin in cartilage tissue engineering

ReviewBones and joints