Pregnancy

Intervention2 papers3 findings

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: Instituto de Salud Carlos III and others

  • Humans2

Associations

2

Chronic kidney disease

upin humans1OR 1.2

1 study
  1. Pregnancy is associated with chronic kidney disease in humans (p for trend = 0.009).

    Humansfemales

    Association between the number of pregnancies and chronic kidney disease in Korean women: a population-based cross-sectional study from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) cohort · Kidney research and clinical practice · 18 Sep 2026

  2. Pregnancy raises the risk of chronic kidney disease in humans (OR 1.20, 95% CI 1.01-1.43).

    Humansfemales

    Association between the number of pregnancies and chronic kidney disease in Korean women: a population-based cross-sectional study from the Korean Genome and Epidemiology Study-Health Examinee (KoGES-HEXA) cohort · Kidney research and clinical practice · 18 Sep 2026

Chronic kidney disease →

Brain age gap

upin humans1

1 study
  1. Pregnancy is associated with brain age gap in humans (Approximately +3 years during pregnancy).

    HumansFirst pregnancybrainDuring pregnancyfemales

    Estimated brain-age gap rises by three years in pregnancy · Research square · 13 Aug 2026 · Preprint

Brain age gap →

Funding

National Heart, Lung, and Blood InstituteUS$11.8mNational Institute of Child Health and Human DevelopmentUS$3.6mNational Institute of Diabetes and Digestive and Kidney DiseasesUS$2.8m39 grants since 2021

Latest

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Research SquareHumansPreprint

Estimated brain-age gap rises by three years in pregnancy

Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal…Brain-age gap estimates rose by about three years during pregnancy and fell below pre-conception levels by 16 months postpartum in a longitudinal study.