AAV-mediated knockdown of LCN2 in aged mice limited microglial inflammation, reduced neuronal pyroptosis, and rescued memory following surgery.AAV-mediated knockdown of LCN2 in aged mice limited microglial inflammation, reduced neuronal pyroptosis, and rescued memory following surgery.
In a longitudinal cohort, lifetime alcohol use disorder was associated with steeper cognitive decline, equivalent to 7.1 additional years of cognitive aging at age 60.In a longitudinal cohort, lifetime alcohol use disorder was associated with steeper cognitive decline, equivalent to 7.1 additional years of cognitive aging at age 60.