DCN

Gene2 papers3 findingsHGNC 2705NCBI Gene 1634Taxon 9606

C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab
  • Animals1
  • Cells1

Effects

3

Osteoarthritis

downin mice1

1 study
  1. DCN prevents osteoarthritis in mice.

    Animalsshown by cartilage-specific deletion in mature micearticular cartilage

    Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging · bioRxiv : the preprint server for biology · 1 Aug 2026 · Preprint

Osteoarthritis →

Aggrecan retention

upin mice1

1 study
  1. DCN improves aggrecan retention in mice.

    Animalsshown by cartilage-specific deletion in mature micearticular cartilage

    Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging · bioRxiv : the preprint server for biology · 1 Aug 2026 · Preprint

Superficial collagen II fibrillar network disruption

downin mice1

1 study
  1. DCN prevents superficial collagen II fibrillar network disruption in mice.

    Animalsshown by cartilage-specific deletion in mature micearticular cartilage

    Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging · bioRxiv : the preprint server for biology · 1 Aug 2026 · Preprint

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