DCN
Gene2 papers3 findingsHGNC 2705NCBI Gene 1634Taxon 9606
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.
- Animals1
- Cells1
Effects
3Osteoarthritis
downin mice1
1 study
Osteoarthritis
downin mice1
DCN prevents osteoarthritis in mice.
Animalsshown by cartilage-specific deletion in mature micearticular cartilage
Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging · bioRxiv : the preprint server for biology · 1 Aug 2026 · Preprint
Aggrecan retention
upin mice1
1 study
Aggrecan retention
upin mice1
DCN improves aggrecan retention in mice.
Animalsshown by cartilage-specific deletion in mature micearticular cartilage
Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging · bioRxiv : the preprint server for biology · 1 Aug 2026 · Preprint
Superficial collagen II fibrillar network disruption
downin mice1
1 study
Superficial collagen II fibrillar network disruption
downin mice1
DCN prevents superficial collagen II fibrillar network disruption in mice.
Animalsshown by cartilage-specific deletion in mature micearticular cartilage
Decorin-mediated Extracellular Matrix Stabilization Maintains Cartilage Integrity During Aging · bioRxiv : the preprint server for biology · 1 Aug 2026 · Preprint