Cognitive age gap

1. Brain age gap mediates cognitive age gap in humans (18.0% of total effect).

   “BAG partly explained the relationship between PC2 and CAG (partial mediation of 18.0% of total effect, p = 0.027”

   Humansmediates relationship between PC2 (Active Life) and CAGbrainn = 211

   Lifestyle and health signatures of brain pathological and cognitive aging · AAIC 2025 abstract · 8 Jan 2026

2. Brain age gap mediates cognitive age gap in humans (18.0% of total effect, p = 0.027).

   “BAG partly explained the relationship between PC2 and CAG (partial mediation of 18.0% of total effect, p = 0.027”

   Humansmediating the relationship between PC2 (Active Life) and CAGbrainn = 211

   Lifestyle and health signatures of brain pathological and cognitive aging · AAIC 2025 abstract · 23 Dec 2025

Brain age gap →