Synergistic Neurodegeneration in Alzheimer's Disease with Lewy Body Co‐Pathology: Insights from Deep Learning and CSF α‐Synuclein Seed Amplification Assays

Abstract

Background: Alzheimer's disease (AD) and Lewy body (LB) pathology frequently co‐occur. While α‐synuclein accumulation characterizes LB pathology, its impact on brain aging, atrophy, and function when combined with AD remains poorly understood.