Weight loss intervention

1. Weight loss intervention decreases CD36+ extracellular vesicles in humans (-1.9-fold).

   “We saw similar responses for the CD36+‐EVs (Figure and Table ), with a 1.6‐fold decrease from baseline (9.6 × 106 EVs/mL) to 1 month (4.2 × 106 EVs/mL; β = −0.46; CI: −0.74 to −0.17; p = 0.002) and 1.9‐fold reduction after 5 months (3.3 × 106 EVs/mL; β = −0.65; CI: −0.93 to −0.36; p < 0.001).”

   Human trial20–24 weeks

   Circulating Liver-Derived and CD36⁺ Extracellular Vesicles Correlate With Ectopic Liver Fat and Markers of Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease and Decrease During Weight Loss Intervention

   Journal of extracellular vesicles·Mar 1, 2026

2. Weight loss intervention decreases CD36+ extracellular vesicles in MASLD.

   “During intervention, levels of both ASGR1+-EVs, CD36+-EVs and ASGR1+CD36+-EVs were significantly decreased in the MASLD group already at 1 month and further reduced after 5 months.”

   Human trialin MASLD

   Circulating Liver-Derived and CD36⁺ Extracellular Vesicles Correlate With Ectopic Liver Fat and Markers of Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease and Decrease During Weight Loss Intervention

   Journal of extracellular vesicles·Mar 1, 2026

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1. Weight loss intervention showed no clear effect on brain age gap in humans (Look AHEAD).

   “the weight-loss intervention did not significantly alter BAG at follow-up (p > 0.05)”

   Human trialLook AHEADbrain10-year follow-up

   Type 2 diabetes and obesity linked to faster brain aging

   AHA Scientific Sessions 2026 abstract·Nov 2, 2026

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1. Weight loss intervention showed no clear effect on transendothelial electrical resistance in humans.

   “we found no difference in TEER between the CR and CR+WL groups and no significant intervention effects on sEVAT characteristics or TEER”

   Human trial72 hn = 29

   Adipose tissue-derived small extracellular vesicles and blood-brain barrier function in adults with overweight and obesity

   Experimental physiology·Jan 28, 2026

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1. Weight loss intervention decreases body mass index in schizophrenia spectrum disorders with comorbid obesity (p < 0.001).

   “There was a significant reduction in BMI (p < 0.001) between two timepoints.”

   Human trialin schizophrenia spectrum disorders with comorbid obesityn = 48

   The effect of weight loss on brain age in schizophrenia spectrum disorders

   PLOS mental health·Sep 2, 2025

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1. Weight loss intervention impairs cognitive function in humans (type 2 diabetes).

   “The weight loss intervention left a legacy of relatively lower cognitive functioning among women”

   Human trialtype 2 diabetesfemales

   Associations between cognitive function and endogenous levels of estradiol and testosterone in adults with type 2 diabetes

   Journal of diabetes and its complications·Jul 26, 2022

1. Weight loss intervention showed no clear effect on epigenetic age in humans.

   “In unadjusted intent-to-treat models, when compared to placebo, no treatment arm demonstrated any statistically significant differences or notable trends for any EA marker.”

   Human trial6 monthsn = 192

   An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors

   Clinical epigenetics·Dec 17, 2021

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1. Weight loss intervention decreases telomere shortening in humans.

   “significant intervention impacts in delaying telomere shortening, with relatively consistent significant results emerged from weight-loss interventions”

   Review

   The Impact of Health Promotion Interventions on Telomere Length: A Systematic Review

   American journal of health promotion : AJHP·Feb 27, 2020

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1. Weight loss intervention is associated with body weight in humans (5% to 20%).

   “response to a weight loss program may range from a weight gain to a greater than expected weight loss”

   Review

   About Unsuccessful Responders to Diet and Physical Activity Interventions: A Focus on Energy Balance and Body-Weight Loss

   Nutrients·Jan 7, 2026