COX7RP

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funders: Japan Agency for Medical Research and Development and 3 more

Animals1

Effects

Senescence-associated secretory phenotype (SASP)

downin mice1

1 study

COX7RP decreases senescence-associated secretory phenotype (SASP) in mice.
“Single-nucleus RNA-sequencing (snRNA-seq) revealed that senescence-associated secretory phenotype genes were downregulated in old COX7RP-Tg white adipose tissue (WAT) compared with old WT WAT, particularly in adipocytes.”
AnimalsCOX7RP-transgenic (COX7RP-Tg)white adipose tissue
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
Aging cell18 Nov 2025

More on Senescence-associated secretory phenotype (SASP)

NAD+

upin mice1

1 study

COX7RP increases NAD+ in mice.
“Moreover, COX7RP-Tg mice exhibited elevated ATP and nicotinamide adenine dinucleotide levels, reduced ROS production, and decreased senescence-associated β-galactosidase levels.”
AnimalsCOX7RP-transgenic (COX7RP-Tg)
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
Aging cell18 Nov 2025

Latest

1 in 12 months

Aging Cell19 Nov

Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice

Experiments in miceOxidative phosphorylation

Paper

COX7RP

Effects

Latest

Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice

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