Brain and nerves
Body system478 papersUBERON 0001016
- Human trial22
- Humans283
- Animals46
- Model organisms11
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Latest
475Daily activity patterns alter cognitive links to widowhood
In 4,427 older Chinese adults followed across three survey waves, lower cognitive function linked to widowhood occurred primarily in passive and…In 4,427 older Chinese adults followed across three survey waves, lower cognitive function linked to widowhood occurred primarily in passive and television-dominant sedentary activity patterns.
Combined frailty and metabolic index tracks multimorbidity risk
Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic…Across 5,586 Chinese adults, each standard-deviation increment in CTI-FI was associated with a 1.342 hazard ratio for incident cardiometabolic multimorbidity.
Early cognitive frailty can reverse in rural older adults
In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical…In rural older adults, transition intensity from reversible cognitive frailty was 0.429 toward cognitive impairment alone and 0.291 toward physical frailty, versus 0.224 toward further deterioration.
Hypothalamic tau impairs pair bonding in male prairie voles
Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their…Expressing mutant tau in the paraventricular hypothalamus stopped 18-month-old male prairie voles from forming selective bonds and altered their oxytocin signaling.
White matter tract changes link to phishing risk in older adults
In 46 older and 51 younger adults, altered integrity in two social brain tracts partly mediated age-related vulnerability to email phishing.In 46 older and 51 younger adults, altered integrity in two social brain tracts partly mediated age-related vulnerability to email phishing.
Exercise, Glucose and Lactate Metabolism in Mild Cognitive Impairment: A Narrative Review
The immunoproteasome in Alzheimer's disease: a dual regulator of tau pathology and microglial senescence
Higher neuroticism links to broad disease risks in Chinese adults
In 25,041 Chinese adults, high neuroticism scores were linked to 1.17- to 1.81-fold higher risks of major physical and mental conditions compared to…In 25,041 Chinese adults, high neuroticism scores were linked to 1.17- to 1.81-fold higher risks of major physical and mental conditions compared to low scores.
Probable REM sleep disorder links to Lewy body dementia
In a memory clinic cohort, probable REM sleep behaviour disorder was linked to incident Lewy body dementia with a hazard ratio of 4.82.In a memory clinic cohort, probable REM sleep behaviour disorder was linked to incident Lewy body dementia with a hazard ratio of 4.82.
Education links to better cognition independent of brain pathology
Across two aging cohorts spanning normal cognition to mild Alzheimer’s disease, higher education tracked with better cognitive performance even after…Across two aging cohorts spanning normal cognition to mild Alzheimer’s disease, higher education tracked with better cognitive performance even after adjusting for multimodal brain pathology.
Cardiometabolic disease and depression link to daily disability
In a longitudinal study of 16,780 older adults over eight years, cardiometabolic multimorbidity and depression together were tied to steeper rises in…In a longitudinal study of 16,780 older adults over eight years, cardiometabolic multimorbidity and depression together were tied to steeper rises in daily living disability.
Aspirin initiation before 65 links to lower Alzheimer's risk
Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident…Across electronic health records and insurance claims databases, starting aspirin before age 65 was consistently associated with lower incident Alzheimer’s disease risk.
Brain signatures of BMI detect systemic disease better than BMI
Across six human cohorts and a 2.3-year follow-up, neural networks identified brain structural patterns tied to cardiometabolic and pulmonary…Across six human cohorts and a 2.3-year follow-up, neural networks identified brain structural patterns tied to cardiometabolic and pulmonary conditions.