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3Simulated microgravity raises transcriptomic age in organoids
Human neural, cardiac, and tonsil organoids exposed to 24 hours of simulated microgravity showed tissue-specific changes, including higher…Human neural, cardiac, and tonsil organoids exposed to 24 hours of simulated microgravity showed tissue-specific changes, including higher transcriptomic-age estimates in brain and heart models.
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer…The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
Microplastics induce senescence in human brain organoids
Exposures to synthetic and ocean-derived micro- and nanoplastics activated senescence pathways and altered neuronal network activity in…Exposures to synthetic and ocean-derived micro- and nanoplastics activated senescence pathways and altered neuronal network activity in region-specific cortical organoids.