Sirtuin 1

1. Caffeinated coffee increases sirtuin 1 in humans (p = 0.033).

   “only Sirtuin-1 increased after caffeinated coffee (p = 0.033) in group B”

   Human trialin lower BMI group28 daysn = 15

   BMI-Dependent Modulation of the Soluble RAGE-Sirtuin-1 Axis by Coffee Type in Coronary Artery Disease

   Nutrients·14 Jul 2026

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1. Smoking increases sirtuin 1 in humans.

   “Sirtuin 1 levels were significantly higher in healthy smokers than in controls”

   Humansin healthy smokers versus controls

   Association of sirtuin 1 rs10997868 and rs730821 polymorphisms with sirtuin 1 and hydroxy-2'-deoxyguanosine levels in healthy smokers: A case-control study

   The Journal of international medical research·1 Oct 2025

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