Otulin knockdown
Intervention1 paper1 finding
- Cells1
Outcomes
1Loss of proteostasis
upin cells1
1 study
Loss of proteostasis
upin cells1
Otulin knockdown increases loss of proteostasis in cells.
Cells
Excess linear ubiquitination disrupts aggregate clearance and impairs proteostasis in cells · The EMBO journal · 28 Sep 2026
Latest
1CellsBrain aging
Excess linear ubiquitination disrupts aggregate clearance and impairs proteostasis in cells
Inactivating the ligase HOIL-1 solidifies dynamic protein condensates and impairs the autophagic clearance of tau, amyloid-beta, and alpha-synuclein aggregates.