Differential effects of amyloid-β and tau on UCH gene expression in Drosophila models of Alzheimer's disease
Gene · Arayesh MJ et al. · Paper published 1 Oct 2026
We haven’t written this paper up. Its abstract belongs to the publisher, so read it at the source.
The paper
Differential effects of amyloid-β and tau on UCH gene expression in Drosophila models of Alzheimer's disease
Arayesh MJ, Ataellahi F, Masoudi R
Gene · 1 Oct 2026 · Peer-reviewed
- Relevance
- Relevant
- News value
- Routine
- Evidence
- Model organisms
- Status
- Peer-reviewed
More on Brain aging
See allHuman neurons accumulate far more mutations over lifespan than shorter-lived mammals
Cortical neurons gain mutations at similar yearly rates across six species, leaving aged humans with uniquely high mutational burdens and transcriptomic dysregulation.
bioRxiv : the preprint server for biology · Caglayan E et al.
CAR T cells targeting inflammatory bone marrow progenitors restore cognition in aged mice
Clearing these peripheral myeloid cells remodeled brain macrophages and improved cognitive performance without requiring the engineered immune cells to enter the brain.
bioRxiv · Harris AS et al.
Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
bioRxiv · R. Carvalho D et al.
Directly converted human neuronal spheroids preserve donor age and model Alzheimer disease
The three-dimensional cell platform maintains biological aging markers while spontaneously developing hallmark pathologies of sporadic Alzheimer disease.
bioRxiv · Alsolami S et al.
Auditory nerve myelin degeneration defines a subtype of age-related hearing loss
Researchers linked poor auditory nerve synchrony and myelin degradation to amplified communication difficulties in older humans, beyond standard hearing thresholds.
medRxiv : the preprint server for health sciences · Harris KC et al.