Synucleinopathies
Disease4 papers1 findingMeSH D000080874
- Model organisms1
Upstream
1Loss of proteostasis
mediatesin humans1
1 study
Loss of proteostasis
mediatesin humans1
Loss of proteostasis mediates synucleinopathies in humans.
Reviewdepending on clearance capacity of diverse aggregates
Differential proteostasis imbalance and the molecular basis of distinct synucleinopathies and tauopathies · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1 Oct 2026
Latest
5Cellular and systemic modifiers of alpha-synuclein proteostasis
ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Differential proteostasis imbalance and the molecular basis of distinct synucleinopathies and tauopathies
ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Alpha-synuclein impairs triglyceride metabolism and mitochondrial structure in aging nematodes
Restoring lipid balance through medium-chain triglycerides or fatty acid inhibition protected worms from alpha-synuclein-driven movement deficits.
EMBO reports · Zhang T et al.
Breaking the proteasome balance: α-synuclein and the ubiquitin-proteasome system
ReviewFrontiers in cell and developmental biology