Cell Death & Disease
Lowering a protein reduced drug sensitivity in senescent cells
In laboratory experiments, reducing the protein weakened two drugs’ cell-killing effects without changing the usual signs of senescence, a state in which cells stop…In laboratory experiments, reducing the protein weakened two drugs’ cell-killing effects without changing the usual signs of senescence, a state in which cells stop dividing.
Experiments in senescent cells and aged miceCellular senescence
Limit: Drug doses were not reported, limiting interpretation of the reduced drug sensitivity