3 papers
National Institute on AgingUS$4.8mNational Institute of Diabetes and Digestive and Kidney DiseasesUS$2.8mNational Institute of Neurological Disorders and StrokeUS$1.1m
Circadian regulation of mitochondrial function by muscle RORs to promote healthy aging
National Institute on AgingUniversity of Texas Hlth Sci Ctr HoustonUS$497.2k2024–2026
National Institute of Neurological Disorders and StrokeTexas A&m University Health Science CtrUS$378.8k2022–2027
National Institute on AgingMassachusetts General HospitalUS$128.4k2023–2028
The 11S-associated immunoproteasome in mitochondrial function and metabolic disorders
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of MinnesotaUS$407.9k2023–2027
National Institute on AgingJohns Hopkins UniversityUS$662.4k2024–2028
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of California, San DiegoUS$852.2k2018–2030
Mitochondrial function regulates ROS-mediated patterning following injury
National Institute of Child Health and Human DevelopmentMaineHealthUS$562.5k2024–2029
National Institute on AgingAugusta UniversityUS$54k2022–2025
Cerebrovascular Mitochondrial Function in Aging and Ischemic Injury
National Institute on AgingUniversity of Alabama at BirminghamUS$247.5k2021–2026
National Institute on AgingMassachusetts General HospitalUS$332.1k2024–2027
Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.
In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated…In laboratory experiments, roflumilast and rolipram lengthened roundworm lifespan by activating a signalling pathway that improved mitochondrial function and alleviated oxidative stress.
Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.
A screen of 3,985 bacterial strains identified an iron-gathering molecule whose effects in worms depended on a stress response in cells’ energy-producing structures.A screen of 3,985 bacterial strains identified an iron-gathering molecule whose effects in worms depended on a stress response in cells’ energy-producing structures.
In mice, restoring the hormone osteocalcin improved motor function in old age by supporting cellular recycling and energy production in spinal motor neurons.In mice, restoring the hormone osteocalcin improved motor function in old age by supporting cellular recycling and energy production in spinal motor neurons.
An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.